
Minimum System Requirements
- OS: Windows XP/Vista
- Processor: Intel Pentium 4 @ 3.0 GHz
- Memory: 512 Mb
- Hard Drive: 8 Gb free
- Video Memory: 256 Mb
- Video Card: nVidia GeForce 6600
- Sound Card: DirectX Compatible
- DirectX: 9.0c
- Keyboard
- Mouse
- DVD Rom Drive

OS: Windows XP/Vista
Processor: Intel Core 2 DUO @ 2.8 GHz
Memory: 1 Gb
Hard Drive: 8 Gb free
Video Memory: 512 Mb
Video Card: nVidia GeForce 8600
Sound Card: DirectX Compatible
DirectX: 9.0c or 10
Keyboard
Mouse
Other Controllers: Game pad
DVD Rom Drive



Shocked by the treachery of the Order, Nero fights Agnus but is mortally wounded by him, which fully unlocks his demonic power which mends the broken Yamato and sends it flying into his hand. Nero destroys the lab with his demonic power, and Agnus flees to inform Sanctus, who suggests using Kyrie against Nero in their next encounter while Gloria assumes Nero's old mission of finding Dante. Wrestling with the fact that he is not human, but in fact a devil as well, Nero continues onward to confront the Order. Fighting the creatures spawned from Agnus's Hell Gates, Nero eventually rejoins with Credo who he discovers to his dismay to be a part of the conspiracy as well and they battle. But their fight is interrupted by Agnus who brings Kyrie to see Nero's trasformation into a devil, which makes her lose her faith in Nero. Agnus then kidnaps Kyrie and departs. Credo, stunned by The Order's blatant use of his sister, is shaken in his belief and apologizes to Nero, promising to return once he has investigated Sanctus's true intentions.

Agnus under the city, opens the hell gate with Yamato, which releases countless demons upon the city. Using The Savior to defeat the oncoming demons, Sanctus enacts his ultimate plan by putting the city through hell and then acting as their "Savior" Sparda, in order to raise the people's faith and worship. Dante, making his way through Fortuna, succeeds in destroying all the hell gates and kills Agnus, sealing the final hell gate. Finally taking on The Savior, Dante takes Yamato and drives it through the Savior's chest, where Nero reclaims it inside. Facing Sanctus, Nero sees Sanctus's twisted interpretation of Sparda's will and defeats him, freeing Kyrie in the process. In the aftermath, Nero returns Sparda to Dante when The Savior awakens, having absorbed Sanctus. Destroying this final demon, Nero makes peace with his arm and sees Dante off.Having already returned Yamato, Nero attempts to give it back, but Dante, instead, entrusts Yamato with Nero saying that since Vergil's sword means so much to him, "That's the only kind of gift worth giving." Nero asks before Dante leaves if the two will ever meet again, and Dante only responds with a wave of his two fingers without turning around and leaves. Nero and Kyrie reconcile in the ruins of Fortuna. Stating that he is the most human person she has ever known, also that he is the one she wants to be with, despite his demonic heritage, they are about to kiss when they are interrupted by scarecrow demons. Nero readily goes to face them off.
Meanwhile, Lady returns to the Devil May Cry office where she had formerly hired Dante to go to Fortuna. Having completed the job, Lady offers a menial reward citing that Dante and Trish's presence escalated the simple job she had asked into the situation it became. As Trish and Lady argue over the reward money, they drag Dante into the argument while he reads a magazine. Unenthusiastically, Dante accepts the small reward as a phone call interrupts Lady exiting the shop. Trish answers and reveals that the caller is offering a job, which Dante happily accepts. As Dante suits up, Lady excitedly asks Dante if she can come along, to which Dante laughs and says, "Do what you want, but don't expect to get paid!" As the trio bursts through the door, Dante, Lady, and Trish all pose as Dante says, "Come on babes. Let's Rock!" and fires repeatedly at the screen.